• The Dow Jones Industrial Average .DJI closed down 29.58 points, or 0.14 percent, to 20,924.76. The S&P500 .SPX lost 6.92 points, or 0.29 percent, to 2,368.39 and the Nasdaq Composite .IXIC dropped 15.25 points, or 0.26 percent, to 5,833.93.
A gauge of global stock markets slipped on Tuesday as the Dow and S&P 500 notched their first back-to-back losses in more than a month, while expectations the Federal Reserve will raise interest rates supported the U.S. dollar.
Shares of large U.S. pharmaceutical and biotechnology companies sold off after a tweet from U.S. President Donald Trump on the need to lower drug prices. Shares of Pfizer Inc (PFE.N) and Amgen Inc (AMGN.O) each dropped more than 1 percent.
• Asian equities were in the red on Wednesday amid mounting geopolitical risks in the region and rising expectations that the Federal Reserve would tighten monetary policy next week.
In Japan, the Nikkei 225 fell 0.37 percent as the yen strengthened against the greenback.
• Geopolitical risks in Asia are mounting, with the arrival of the first components of a U.S.-deployed Terminal High-Altitude Area Defense (THAAD) anti-missile system in South Korea.
The deployment of the system drew strong rebuke from China, even though the U.S. state department said it has told China that the deployment of THAAD anti-missile system is no threat to china, but a response to North Korea's latest missile test.
Reference: Reuters, CNBC
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