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U.S. stocks dropped on Tuesday as investors fretted about Britain's exit from the European Union and the prospect of a Federal Reserve interest rate hike in coming months.

It was the second straight session of losses on Wall Street, where investors were already on edge due to the uncertainty of a tight race ahead of the Nov. 8 presidential election.

The Dow Jones industrial average .DJI fell 0.47 percent to end at 18,168.45 and the S&P 500 .SPX lost 0.5 percent to 2,150.49.

Asian shares and gold retreated on Wednesday and bond yields were near two-week highs after markets were rattled by a report flagging the possible withdrawal of global stimulus measures.

MSCI's broadest index of Asia-Pacific shares outside Japan .MIAPJ0000PUS slid 0.5 percent in early trading. Japan's Nikkei .N225 gained 0.1 percent, aided by a weaker yen.

Bloomberg reported on Tuesday that the European Central Bank (ECB) would probably wind down its 80 billion euro ($90billion) monthly bond purchases gradually before ending its quantitative easing program, citing unnamed officials at euro zone countries' central banks.