MSCI's broadest index of Asia-Pacific shares outside Japan dipped 0.8 percent, but remains poised for a weekly gain of 1.4 percent.
"There are concerns over Brexit as polls seem to suggest the probability of Britain leaving Europe is rising," said Tatsushi Maeno, managing director at PineBridge Investments.
"You can't buy risk assets under such conditions even if you want to," he said.
Japan's Nikkei share average fell on Friday after 10-year government bond yields dropped to a record low, rattling investors who were already cautious ahead of policy decisions from the U.S. Federal Reserve and Bank of Japan next week.
The Nikkei fell 0.4 percent to 16,601.36 points. For the week, it dropped 0.2 percent.
Hong Kong stocks fell on Friday as traders took profits on recent gains after reports that billionaire investor George Soros, a noted pessimist on China, was making big, bearish bets again.
The Wall Street Journal reported on Thursday that Soros Fund Management has expressed concern about global economic outlook, China capital flight, reserve depletion, and internal politics.
The Hang Seng index dropped 0.7 percent to 21,152.99 points by the lunchbreak. The Hong Kong China Enterprises Index lost 1.5 percent to 8,890.12.
Reference: Financial Express, CNBC,Reuters,MoneyControl,The Star,Gulf News
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