• U.S. share futures and the dollar tumbled on Wednesday on worries about more U.S. political turmoil after media reports said President Donald Trump asked then-FBI Director James Comey to end a probe into Trump's former national security advisor.
MSCI's broadest index of Asia-Pacific shares outside Japan .MIAPJ0000PUS dropped 0.3 percent while Japan's Nikkei .N225 shed 0.5 percent.
• Japanese stocks dropped on Wednesday after the dollar eased against the yen on weak U.S. economic data, while financial stocks underperformed hit by lower U.S. yields.
The Nikkei shares average fell 0.5 percent to 19,814.88.
• China stocks snapped a four-day winning streak to end lower on Wednesday, as investors remained cautious amid lingering concerns over tighter regulation and economic growth despite recent soothing regulatory comments.
The blue-chip CSI300 index fell 0.5 percent, to 3,409.97 points, while the Shanghai Composite Index lost 0.3 percent to 3,104.44 points.
• Hong Kong stocks eased on Wednesday but held near 21-month highs aided by steady flows of money from mainland China, where shares tanked under the weight of tighter regulations.
The Hang Seng index fell 0.2 percent, to 25,293.63, while the China Enterprises Index lost 0.5 percent, to 10,383.14 points.
Reference: Reuters, CNBC